2 definitions found From The Collaborative International Dictionary of English v.0.48 [gcide]: mainline \main"line`\ (m[=a]n"l[imac]n`) v. t. 1. to inject (illegal drugs) into the vein; as, he preferred to mainline heroin rather than sniff coke. [WordNet 1.5] From WordNet (r) 2.0 [wn]: mainline v : inject into the vein; "She is mainlining heroin"
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