3 definitions found From The Collaborative International Dictionary of English v.0.48 [gcide]: Heartache \Heart"ache`\ (-[=a]k`), n. [Cf. AS. heortece.] Sorrow; anguish of mind; mental pang. --Shak. [1913 Webster] From WordNet (r) 2.0 [wn]: heartache n : intense sorrow caused by loss of a loved one (especially by death) [syn: {grief}, {heartbreak}, {brokenheartedness}] From Moby Thesaurus II by Grady Ward, 1.0 [moby-thes]: 35 Moby Thesaurus words for "heartache": aching heart, affliction, agony, agony of mind, anguish, bale, bitterness, bleeding heart, broken heart, brokenheartedness, care, crushing, depression, depth of misery, desolation, despair, dole, extremity, grief, heartbreak, heartbrokenness, heartsickness, heartsoreness, heavy heart, infelicity, melancholia, melancholy, misery, prostration, regret, rue, sadness, suicidal despair, woe, wretchedness
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