1 definition found From The Collaborative International Dictionary of English v.0.48 [gcide]: Deplete \De*plete"\, v. t. [imp. & p. p. {Depleted}; p. pr. & vb. n. {Depleting}.] [From L. deplere to empty out; de- + plere to fill. Forined like replete, complete. See {Fill}, {Full}, a.] 1. (Med.) To empty or unload, as the vessels of human system, by bloodletting or by medicine. --Copland. [1913 Webster] 2. To reduce by destroying or consuming the vital powers of; to exhaust, as a country of its strength or resources, a treasury of money, etc. --Saturday Review. [1913 Webster]
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