1 definition found From The Collaborative International Dictionary of English v.0.48 [gcide]: Defatigate \De*fat"i*gate\, v. t. [L. defatigatus, p. p. of defatigare; de- + fatigare to weary. See {Fatigue}.] To weary or tire out; to fatigue. [R.] --Sir T. Herbert. [1913 Webster]
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